EVALUATION OF THE CREATINE KINASE SYSTEM TO MAINTAIN THE VOLUMETRIC BLOOD FLOW RATE IN THE BRAIN IN THE SECOND HALF OF EMBRYOGENESIS AND IN THE FIRST DAYS AFTER HATCHING

Authors

  • Aniypa Samudinovna Turganbayeva institute of mountain physiology and medicine, National Academy of Sciences of the Kyrgyz Republic

Keywords:

chicken embryons, volumetric blood flow velocity, CK-creatine kinase activity, cerebral hemispheres.

Abstract

The relationship between the dynamics of creatine kinase activity in the blood serum and the volumetric blood flow velocity in the cerebral hemispheres in different periods of chicken development was assessed. A uniform increase in blood flow in the brain was accompanied by a uniform increase in the anatomical lumen (D2). internal carotid artery, and maintaining the same level of linear blood flow velocity (V), parietal shear stress (t ~ V/D). development of chick embryos. Such an increase in the activity of CC- (as an energy source) throughout the entire period of embryogenesis can be considered as a physiological mechanism that maintains an increase in the linear velocity of the internal carotid artery (D2) and blood, and the V/D index of the wall of the main arteries at the same level.

References

Козлов В.И. Инструкция по применению лазерного анализатора капиллярного кровотока ЛАКК-01 //В.И. Козлов, Э.С.Мач, В.В. Сидоров. – М., 2002. – 39с.

Садовников Н.В., Придыбайло Н.Д., Верещак Н.А., Заслонов А.С. Общие и специальные методы исследования крови птиц промышленных кроссов. – Екатеринбург – СПб.: Уральская ГСХА, НПП «АВИВАК», 2009. – 85 с.

Турганбаева А. С., Беличенко В. М., Шошенко К. А. Кровоток в головном мозге и печени у кур в эмбриональном и раннем постэмбриональном периодах// Росс. физиол. журн. им. И.М. Сеченова. – 2011 – Т.97 (12): – С. 1361–1372.

Bonilla DA, Kreider RB, Stout JR, et al . Metabolic Basis of Creatine in Health and Disease: A Bioinformatics- Assisted Review. //Nutrients. – 2021 Apr 9; – 13(4):1238. Doi: 10.3390/nu13041238. PMID: 33918657; PMCID: PMC8070484.

Han W., Song M., Yuan H, Bao H., Liu C., Wu C., and Zhao C. Effects of hypoxia on serum hepatic chemistries of Tibet chicken and Shouguang chicken .Afr. J. Biotechnol. 2013 .Vol. 12(46), pp. 6540-6543].

ImagawaT, Yamamoto, E. Sawada, M. Okamoto,M.and Uehara M.Expression of Lactate Dehydrogenase-A and -B Messenger Ribonucleic Acids in Chick Glycogen Body// Poultry Science – 2006. – No 85. – 1232–1238;

Patwari Р., Lee R. T. Mechanical control of tissue morphogenesis.// Circ. Res. – 2008. – 103: – рр. 234–243.

Taber L. A. Biomechanics of cardiovascular development.// Annu. Rev. Biomed. Eng. – 2001–3: – рр.1–25.

Wallimann, T.; Wyss, M.; Brdiczka, D.; Nicolay, K.; Eppenberger, H.M. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The ‘phosphocreatine circuit’ for cellular energy homeostasis.// Biochem. J. – 1992, – 281, рр. 21–40.

Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. //Amino Acids.- 2011 May;40(5) – рр. 1271–96. Doi: 10.1007/s00726-011-0877-3. Epub 2011 Mar 30. PMID: 21448658; PMCID: PMC3080659.

Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000 Jul; 80(3):1107-213.

Doi: 10.1152/physrev.2000.80.3.1107. PMID: 10893433.

Published

2022-09-20

Issue

Section

СЕКЦИЯ ЗДОРОВЬЕ ЧЕЛОВЕКА В НЕБЛАГОПРИЯТНЫХ УСЛОВИЯХ СРЕДЫ